Scientists have tried, and there's literally no way to improve on the fabulous genetic combination that is Murr, Q, Sal, and Joe.
Which is why we think it's about time they made babies together. They need to create a race of little Jokers to dominate the Earth. And if they did? This is probably what it would look like.*
*PS. This isn't what it would look like. This is just the Jokers look like put through a face swap app. But still.