It's safe to say that South Park has skewered a LOT of celebrities in its time, and they've all been hit pretty hard.
Remember the time they basically called Yeezy a gay fish for an entire episode?
Yeah, you do.
But surprisingly, Kanye wasn't the most pissed off about the whole thing.
We know this because at Comic Con co-creators Trey Parker and Matt Stone were asked who was the most pissed off with them after their years of satirical digging.
Almost at the same time, they said: "Sean Penn and Tom Cruise for sure." FOR SURE.
Now, Sean Penn was most pissed off about his appearance in Team America, but Tom Cruise, it's safe to say, was mega-pissed about his appearance in South Park.
Which may have something to do with how much they ripped into his religion, Scientology.
They really did go for it.
So there you have it: after hundreds of celebrity take-downs on South Park over twenty years, Tom Cruise was the most pissed.